研究業績

論文

2024年

• "Structure-Activity Relationship Study of CYM51010, an agonist for the µ-δ Opioid Receptor Heterodimer"
  Ayaka Watanabe,Shuma Yamada,Haruka Yoshida,Miku Inagaki,Nao Atsumi,Aoba Matsushima,Naoki Takahashi,Naoto Ishibashi,Takumi Ogino,Ryoto Someya,Ai Taguchi,Ryo Kagaya,Karin Ashizawa,Hinako Mendori,Yusuke Karasawa,Kaori Ohshima,Akinobu Yokoyama,Miki Nonaka,Kanako Miyano,Fumika Karaki,Shigeto Hirayama,Kennosuke Itoh,Yasuhito Uezono,Hideaki Fujii
  Chemical and Pharmaceutical Bulletin 72, 7, 711-730 (2024).

  • URL
  • DOI: 10.1248/cpb.c24-00188
• "Anti-Schistosomal Activity and ADMET Properties of 1,2,5-Oxadiazinane-Containing Compound Synthesized by Visible-Light Photoredox Catalysis"
  Kennosuke Itoh,Hiroki Nakahara,Atsushi Takashino,Aya Hara,Akiho Katsuno,Yuriko Abe,Takaaki Mizuguchi,Fumika Karaki,Shigeto Hirayama,Kenichiro Nagai,Reiko Seki,Noriko Sato,Kazuki Okuyama,Masashi Hashimoto,Ken Tokunaga,Hitoshi Ishida,Fusako Mikami,Kofi Dadzie Kwofie,Hayato Kawada,Bangzhong Lin,Kazuto Nunomura,Toshio Kanai,Takeshi Hatta,Naotoshi Tsuji,Junichi Haruta,Hideaki Fujii
  RSC Medicinal Chemistry 15, 4001-4010 (2024).

  • DOI: 10.26434/chemrxiv-2024-rh4m7

2022年

• "Visible-Light-Induced formal [3+2] cycloaddition of α, β-unsaturated imides or amide with N,N,N',N'-tetramethyldiaminomethane for the synthesis of 4-alkyl- and 4-arylL-1-methyl-2-pyrrolidinones"
  Kennosuke Itoh,Sho Ito,Shun-ichi Nagao,Ken Tokunaga,Takaaki Mizuguchi,Fumika Karaki,Shigeto Hirayama,Yoshio Shibagaki,Masashi Hashimoto,Hideaki Fujii
  Heterocycles 104, 12, 2169-2178 (2022).

  • DOI: 10.3987/COM-22-14747
• "Visible-Light-Induced synthesis of imidazolidines through formal [3+2] cycloaddition of aromatic imines with N,N,N',N'-tetramethyldiaminomethane"
  Kennosuke Itoh, Nanase Ishii, Atsushi Takashino, Aya Hara, Satoshi Kon, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Kenichiro Nagai, Noriko Sato, Ken Tokunaga, Mitsuaki Suzuki, Masashi Hashimoto, and Hideaki Fujii
  Journal of Photochemistry and Photobiology A: Chemistry 434, 114236-114239 (2022).

  • DOI: 10.1016/j.jphotochem.2022.114239

2021年

• "Catalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air"
  Fumika Karaki,Takuto Kiguchi,Kennosuke Itoh,Noriko Sato,Kazuhide Konishi,Hideaki Fujii
  Tetrahedron 97, 132411 (2021).

  • DOI: 10.1016/j.tet.2021.132411

2020年

• "Visible-Light-Induced synthesis of 1,2,3,4-tetrahydroquinolines via formal [4+2] cycloaddition of acyclic α,β-unsaturated amides and imides with N,N-dialkylanilines (Featured on the Inside Cover)"
  Kennosuke Itoh,Shun-ichi Nagao,Ken Tokunaga,Shigeto Hirayama,Fumika Karaki,Takaaki Mizuguchi,Kenichiro Nagai,Noriko Sato,Mitsuaki Suzuki,Masashi Hashimoto,Hideaki Fujii
  Chem. Eur. J. 27, 16, 5171-5179 (2020).

  • URL
  • DOI: 10.1002/chem.202004186
• "Synthesis of 1,2,5‐oxadiazinane derivatives by photochemical cycloaddition of nitrones with diaminomethanes (Featured on the Inside Cover)"
  Kennosuke Itoh,Atsushi Takashino,Atsushi Ohtsuka,Mizuki Kobe,Shunsuke Sawamura,Ryo Kato,Shigeto Hirayama,Fumika Karaki,Takaaki Mizuguchi,Noriko Sato,Ken Tokunaga,Yasunori Toda,Hiroyuki Suga,Hitoshi Ishida,Hideaki Fujii
  ChemPhotoChem 4, 6, 388-392 (2020).

  • URL
  • DOI: 10.1002/cptc.202000004
• "Discovery of δ opioid receptor full agonists lacking a basic nitrogen atom and their antidepressant-like effects"
  Fuji H,Uchida Y,Shibasaki M,Nishida M,Yoshioka T,Kobayashi R,Honjo A,Itoh K,Yamada D,Hirayama S,Saitoh A
  Bioorg. Med. Chem. Lett. 30, 127176 (2020).

2019年

• "Ligand-Dependent Site-Selective Suzuki Cross-Coupling of 4-Bromopyrazol-5-yl Triflates"
  Sakakibara R,Itoh K,Fujii, H
  J Org Chem 84, 18, 11474-11481 (2019).

  • DOI: 10.1021/acs.joc.9b01306
• "Discovery of δ Opioid Receptor Full Inverse Agonists and Their Effects on Restraint Stress-induced Cognitive Impairment in Mice"
  Hirayama S,Iwai T,Higashi E,Nakamura M,Iwamatsu C,Itoh K,Nemoto T,Tanabe M,Fujii H
  ACS Chem Neurosci 10, 5, 2237-2242 (2019).

  • DOI: 10.1021/acschemneuro.9b00067
• "Novel Asymmetric Photodimerization Reaction of Coumarin Derivatives Bearing a Chiral 2-Oxazolidinone Auxiliary"
  Itoh K,Odate F,Karikomi T,Obe K,Miyamori T,Kamiya H,Yoza K,Nagai K,Fujii H,Suga H,Tokunaga K
  RSC Adv 9, 22, 12365-12369 (2019).

  • URL
  • DOI: 10.1039/C9RA00822E
• "A deprotection procedure using SO3H silica gel to remove non-silyl protecting groups"
  Fumika Karaki,Miki Kuwada,Saki Tajiri,Misaki Kanda,Mari Yanai,Mitsuhiro Kamimura,Kennosuke Itoh,Hideaki Fujii
  Synthetic Communications 49, 212-220 (2019).

  • DOI: 10.1080/00397911.2018.1548023

2018年

• "Enantioselective synthesis of 8-azabicyclo[3.2.1]octanes via asymmetric 1,3-dipolar cycloadditions of cyclic azomethine ylides using a dual catalytic system"
  Hiroyuki Suga,Masahiro Yoshiwara,Takaaki Yamaguchi,Takashi Bando,Mizuki Taguchi,Ayano Inaba,Yuichi Goto,Ayaka Kikuchi,Kennosuke Itoh,Yasunori Toda
  Chemical Communications 55, 1552-1555 (2018).

  • DOI: 10.1039/C8CC09224A
• "The Practical Synthesis of Dissymmetrical 1,3,5-Trioxazatriquinane Derivatives Comprised of Three Distinct Carbonyl Compounds"
  Hirayama S,Obayashi K,Wada N,Ohyama K,Fuku S,Koyano K,Karaki F,Itoh K,Nagase H,Fujii H
  Heterocycles 99, 1003-1019 (2018).

  • DOI: 10.3987/COM-18-S(F)65
• "Lewis Acid Catalysis in Intermolecular [2+2] Photocycloaddition of Coumarin-3-carboxamide Bearing 2-Oxazolidinone Auxiliary with n-Propyl Vinyl Ether and Vinyl Pivalate"
  Itoh K,Matsuura J,Kamiya H,Kudo R,Takahashi Y,Hashimoto Y,Yoza K,Tokunaga K,Fujii H,Suga H
  Heterocycles 97, 591-603 (2018).

  • DOI: 10.3987/COM-18-S(T)44
• "Three-Component Reactions of Diazoesters, Aldehydes, and Imines Using a Dual Catalytic System Consisting of a Rhodium(II) Complex and a Lewis Acid"
  Yasunori Toda,Wakatake Kaku,Makoto Tsuruoka,Sho Shinogaki,Tomoka Abe,Hideaki Kamiya,Ayaka Kikuchi,Kennosuke Itoh,Hiroyuki Suga
  Organic Letters 20, 9, 2659-2662 (2018).

  • DOI: 10.1021/acs.orglett.8b00865

2017年

• "C-Homomorphinan Derivatives as Lead Compounds to Obtain Safer and More Clinically Useful Analgesics"
  Ishikawa K,Karaki F,Tayama K,Higashi E,Hirayama S,Itoh K,Fujii H
  Chem. Pharm. Bull 65, 10, 920-929 (2017).

  • DOI: 10.1248/cpb.c17-00385
• "Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels_Alder Reactions"
  Fumika Karaki,Kenji Ohgane,Hirotaka Imai,Kennosuke Itoh,Hideaki Fujii
  European Journal of Organic Chemistry 2017, 26, 3815-3829 (2017).

  • DOI: 10.1002/ejoc.201700411

2016年

• "Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton"
  Kyoko Ishikawa,Yusuke Mochizuki,Shigeto Hirayama,Toru Nemoto,Kenichiro Nagai,Kennosuke Itoh,Hideaki Fujii
  Bioorganic and Medicinal Chemistry 24, 10, 2199-2205 (2016).

  • DOI: 10.1016/j.bmc.2016.03.040

2015年

• "Photochemically-induced C-C bond formation between tertiary amines and nitrones"
  Kennosuke Itoh,Ryo Kato,Daito Kinugawa,Hideaki Kamiya,Ryuki Kudo,Masayuki Hasegawa,Hideaki Fujii,Hiroyuki Suga
  Organic and Biomolecular Chemistry 13, 33, 8919-8924 (2015).

  • DOI: 10.1039/c5ob01277e
• "Chiral Lewis Acid-Catalyzed Enantioselective Cycloadditions between Indoles and Cyclic Carbonyl Ylides Derived from Diazodiketone or Diazoketoester Derivatives"
  Hiroyuki Suga,Yurie Sekikawa,Shunta Misawa,Daito Kinugawa,Rinnosuke Oda,Kennosuke Itoh,Yasunori Toda,Ryotaro Kiyono
  Journal of Organic Chemistry 80, 13, 6687-6696 (2015).

  • DOI: 10.1021/acs.joc.5b00835

2013年

• "Chiral Lewis acid catalyzed asymmetric cycloadditions of carbonyl ylides generated from diazoimide derivatives and their synthetic applications to indolizidine alkaloids"
  Hiroyuki Suga,Yuta Hashimoto,Shingo Yasumura,Ryota Takezawa,Kennosuke Itoh,Akikazu Kakehi
  Journal of Organic Chemistry 78, 21, 10840-10852 (2013).

  • DOI: 10.1021/jo401837d
• "Diastereoselective synthesis of tetrahydrofurans by Lewis acid catalyzed intermolecular carbenoid-carbonyl reaction-cycloaddition sequences: Unusual diastereoselectivity of Lewis acid catalyzed cycloadditions"
  Yuta Hashimoto,Kennosuke Itoh,Akikazu Kakehi,Motoo Shiro,Hiroyuki Suga
  Journal of Organic Chemistry 78, 12, 6182-6195 (2013).

  • DOI: 10.1021/jo400858u

2012年

• "Reactions of 3-[bis(methylthio)methylene]-2(3H)-imidazo[1,2-A]pyridinones with quinolinium and isoquinolinium N-unsubstituted aminides"
  Akikazu Kakehi,Takashi Abe,Hiroyuki Suga,Kennosuke Itoh
  Heterocycles 86, 2, 1507-1516 (2012).

  • DOI: 10.3987/COM-12-S(N)42
• "Novel rearrangements of a 8aH-pyrido[1,2-d]thieno[2',3'-b][1,4]thiazepine derivative"
  Akikazu Kakehi,Kennosuke Itoh,Hiroyuki Suga,Yuuki Ohkubo,Ayaka Kobayashi,Takashi Nishi
  Heterocycles 85, 2, 305-312 (2012).

  • DOI: 10.3987/COM-11-12398
• "Molecular recognition of 2-(Arylmethylthio)-indolizine derivatives through an intramolecular arene-φ(Cation) interaction"
  Akikazu Kakehi,Kennosuke Itoh,Hiroyuki Suga,Nobuhiro Yamaguchi,Takashi Abe,Yohei Yuda,Haruka Katsumata
  Heterocycles 84, 2, 753-764 (2012).

  • DOI: 10.3987/COM-11-S(P)50

2011年

• "Asymmetric cycloaddition reactions of diazoesters with 2-alkenoic acid derivatives catalyzed by binaphthyldiimine-Ni(II) complexes"
  Hiroyuki Suga,Yasuhisa Furihata,Atsushi Sakamoto,Kennosuke Itoh,Yukihisa Okumura,Teruko Tsuchida,Akikazu Kakehi,Toshihide Baba
  Journal of Organic Chemistry 76, 18, 7377-7387 (2011).

  • DOI: 10.1021/jo201061f
• "Unexpected formation of thiino[3',4':4,5]oxazolo[l,3-b]-[l,3]oxazepine derivatives1"
  Akikazu Kakehi,Kennosuke Itoh,Hiroyuki Suga,Hirofumi Kobayashi,Hideyuki Muranaka,Motoo Shiro
  Heterocycles 83, 5, 1013-1016 (2011).

  • DOI: 10.3987/COM-11-12157

2010年

• "Preparation of new nitrogen-bridged heterocycles 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]- pyridine derivatives"
  Akikazu Kakehi,Hiroyuki Suga,Yukihisa Okumura,Kennosuke Itoh,Kouji Kobayashi,Yoshihiro Aikawa,Kotaro Misawa
  Chemical and Pharmaceutical Bulletin 58, 11, 1502-1510 (2010).

  • DOI: 10.1248/cpb.58.1502
• "Synthesis of spiro[2-cyclopentene-1,3'-imidazo[1,2-a]-pyridine] derivatives and their interesting behavior in 1H-NMR spectra in deuteriochloroform1"
  Takashi Abe,Akikazu Kakehi,Hiroyuki Suga,Yukihisa Okumura,Kennosuke Itoh
  Heterocycles 81, 9, 2075-2086 (2010).

  • DOI: 10.3987/COM-10-11985
• "Asymmetric 1,3-Dipolar cycloaddition reactions of azomethine imines with acrolein catalyzed by L-proline and its derivatives"
  Hiroyuki Suga,Tadashi Arikawa,Kennosuke Itoh,Yukihisa Okumura,Akikazu Kakehi,Motoo Shiro
  Heterocycles 81, 7, 1669-1688 (2010).

  • DOI: 10.3987/COM-10-11967
• "Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion"
  Yusaku Eda,Kennosuke Itoh,Yoshio N. Ito,Mamoru Fujitsuka,Tetsuro Majima,Toshio Kawato
  Supramolecular Chemistry 22, 9, 517-523 (2010).

  • DOI: 10.1080/10610278.2010.487566
• "A new synthetic approach to some functionalized cycl[3.2.2]azine derivatives"
  Hideyuki Muranaka,Akikazu Kakehi,Hiroyuki Suga,Kennosuke Itoh
  Heterocycles 82, 2, 1251-1266 (2010).

  • DOI: 10.3987/COM-10-S(E)72
• "Preparation of new nitrogen-bridged heterocycles. 69.1 Synthesis and reaction of 1-(α-hydroxybenzyl)thieno-[3,4-b]indolizine derivatives"
  Akikazu Kakehi,Hiroyuki Suga,Yukihisa Okumura,Kennosuke Itoh,Shin Hatayama,Daisuke Kubo,Kouji Kobayashi
  Heterocyclic Communications 16, 1, 53-63 (2010).

  • DOI: 10.1515/HC.2010.16.1.53

2008年

• "2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)"
  Yusaku Eda,Kennosuke Itoh,Yoshio N. Ito,Toshio Kawato
  Tetrahedron 65, 1, 282-288 (2008).

  • DOI: 10.1016/j.tet.2008.10.057

2007年

• "Organocatalysis in Conjugate Amine Additions. Synthesis of β-Amino Acid Derivatives"
  Sibi, M. P,Itoh, K
  J. Am. Chem. Soc. 129, 26, 8064-8065 (2007).

  • DOI: 10.1021/ja071739c

2005年

• "Enantioselective Cycloadditions with α,β-Disubstituted Acrylimides"
  Sibi, M. P,Ma, Z,Prabagaran, N,Itoh, K
  Org. Lett. 7, 12, 2394-2352 (2005).

  • DOI: 10.1021/ol050599d
• "Enantioselective enol lactone synthesis under double catalytic conditions"
  Kennosuke Itoh,Masayuki Hasegawa,Junji Tanaka,Shuji Kanemasa
  Organic Letters 7, 6, 979-981 (2005).

  • DOI: 10.1021/ol047872g

2004年

• "Chiral Lewis Acid Catalysis in Nitrile OxideCycloadditions"
  Sibi M P,Itoh K,Jasperse C P
  J. Am. Chem. Soc. 126, 17, 5366-5367 (2004).

  • DOI: 10.1021/ja0318636

2003年

• "Enantioselective Michael addition reactions of malononitrile catalyzed by chiral Lewis acid and achiral amine catalysts"
  Kennosuke Itoh,Yoji Oderaotoshi,Shuji Kanemasa
  Tetrahedron Asymmetry 14, 6, 635-639 (2003).

  • DOI: 10.1016/S0957-4166(03)00084-3
• "A new method for enol lactone synthesis by a Michael addition/cyclization sequence"
  Kennosuke Itoh,Shuji Kanemasa
  Tetrahedron Letters 44, 9, 1799-1802 (2003).

  • DOI: 10.1016/S0040-4039(03)00147-3

2002年

• "Enantioselective Michael additions of nitromethane by a catalytic double activation method using chiral Lewis acid and achiral amine catalysts"
  Kennosuke Itoh,Shuji Kanemasa
  Journal of the American Chemical Society 124, 45, 13394-13395 (2002).

  • DOI: 10.1021/ja027313+

1998年

• "Synthesis of theA/B/C Ring System of Taxane Diterpenes from (S)-(+)-Carvone"
  Hirai, Y,Ito, K,Nagaoka, H
  Heterocycles 48, 2, 235-238 (1998).

  • DOI: 10.3987/COM-97-8055